Rosen JG, Ndyanabo A, Nakawooya H, Galiwango RM, Ssekubugu R, Ssekasanvu J, Kim S, Rucinski KB, Nakigozi G, Nalugoda F, Kigozi G, Quinn TC, Chang LW, Kennedy CE, Reynolds SJ, Kagaayi J, Grabowski MK. Incidence of health facility switching and associations with HIV viral rebound among persons on antiretroviral therapy (ART) in Uganda: a population-based study. Clin Infect Dis. 2023 Dec 19:ciad773. doi: 10.1093/cid/ciad773. Epub ahead of print. PMID: 38114162.
Abstract
Background:
A substantial fraction of persons on antiretroviral therapy (ART) considered lost to follow-up have actually transferred their HIV care to other facilities. However, the relationship between facility switching and virologic outcomes, including viral rebound, is poorly understood.
Methods:
We used data from 40 communities (2015-2020) in the Rakai Community Cohort Study to estimate incidence of facility switching and viral rebound. Persons aged 15-49 years with serologically confirmed HIV infection self-reporting ART use and contributing ≥1 follow-up visits were included. Facility switching and virologic outcomes were assessed between two consecutive study visits (i.e., index and follow-up visits, ∼18-month interval). Those reporting different HIV treatment facilities between index and follow-up study visits were classified as having switched facilities. Virologic outcomes included viral rebound among individuals initially suppressed (<200 copies/mL). Multivariable Poisson regression was used to estimate associations between facility switching and viral rebound.
Results:
Overall, 2,257 persons self-reporting ART use (median age: 35 years, 65% women, 92% initially suppressed) contributed 3,335 visit-pairs and 5,959 person-years (py) to the analysis. Facility switching was common (4.8 per 100 py, 95%CI 4.2-5.5) and most pronounced in persons <30 years and fishing community residents. Among persons suppressed at their index visit (n=2,076), incidence of viral rebound was over twice as high in persons who switched facilities (adjIRR=2.27, 95%CI 1.16-4.45).
Conclusions:
Facility switching was common and associated with viral rebound among persons initially suppressed. Investments in more agile, person-centered models for mobile clients are needed to address system inefficiencies and bottlenecks that can disrupt HIV care continuity.