High frequency of false positive HCV ELISA in Rakai, Uganda

November 30, 2013 by
RHSP

Mullis CE, Laeyendecker O, Reynolds SJ, Ocama P, Quinn J, Boaz I, Gray RH, Kirk GD, Thomas DL, Quinn TC, Stabinski L.

Clin Infect Dis. 2013 Dec;57(12):1747-50. doi: 10.1093/cid/cit602. Epub 2013 Sep 18. PMCID: PMC3840403


Abstract

The prevalence of hepatitis C virus (HCV) infection in sub-Saharan Africa remains unclear. We tested 1000 individuals from Rakai, Uganda, with the Ortho version 3.0 HCV enzyme-linked immunosorbent assay. All serologically positive samples were tested for HCV RNA. Seventy-six of the 1000 (7.6%) participants were HCV antibody positive; none were confirmed by detection of HCV RNA.

Keywords: Africa; ELISA; hepatitis C virus.

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