Prodger JL , Gray R H, Kigozi G , Nalugoda F , Galiwango R , Nehemiah K , Kakanga M , Hirbod T , Wawer MJ , Sewankambo N , Serwadda D , Kaul R ; Rakai Genital Immunology Research Group
AIDS. 2012 Jun 19;26(10):1319-22. doi: 10.1097/QAD.0b013e328354675c. PMID: 22516874
Abstract
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.