Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda.

May 31, 2019 by
Peace Mirembe (V3locity)

Saylor D, Nakigozi G, Pardo CA, Kisakye A, Kumar A, Nakasujja N, Robertson KR, Gray RH, Wawer MJ, Sacktor N.

J Neurovirol. 2019;25(3):410-4.


Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

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